In vitro sensitivity testing of human renal cell carcinoma with cytostatic agents and interferon alpha-2a
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چکیده
منابع مشابه
Correlation Between Interferon Alpha Receptor Protein Expression and Sensitivity to Interferon Alpha Subtypes in Human Renal Carcinoma Cell Lines
1109-6535/2004 $2.00+.40 Abstract. Background: We have previously characterized the antitumor activities and immunological properties of interferon-alpha (IFN-·) subtypes on renal cell carcinoma (RCC). However, the mechanism responsible for the different biologic activities among the IFN-· subtypes is still unclear. To explain the different cellular sensitivities to IFN-· subtypes, detailed exp...
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Recombinant human interferon alpha 2a (rhIFN α -2a) production and cell growth were monitored in a set of genetically modified E. coli strains (MSD1519, MSD1520, MSD 1521, MSD 1522, MSD 1523) producing rhIFN α -2a. The growth was followed at OD 600 nm, changes in cell physiology were detected by pyrolysis mass spectrometry (PyMS) of cell biomass and recombinant protein production was determined...
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A 60-year-old man who had renal cell carcinoma with renal hypofunction underwent partial nephrectomy followed by alpha-interferon therapy (LHBI 3 x 10(6) IU/day intramuscular injection for 4 weeks, then twice a week for 6 months). Glomerular filtration rate slightly decreased to 28. 5 from 32.6 ml/m after partial nephrectomy. On single injection of IFN, its serum level reached the maximum of 20...
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Human interferon alpha 2a (hIFNα2a) is a cytokine regulating immune system that has been used in hepatitis and cancer treatments. It has wide biological potency covering antiviral, antiproliferative and immunomodulative activities. This mini review discusses Roferon-A as a prominent commercial product of recombinant hIFNα2a which is produced in bacterial system, Escherichia coli, as therapeutic...
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ژورنال
عنوان ژورنال: Urological Research
سال: 1991
ISSN: 0300-5623,1434-0879
DOI: 10.1007/bf00368182